An enigma finally solved DNA BREAKS

Among the various types of radiation-induced DNA damage, double-strand breaks specifically are considered to be the key lesion tied to the lethal effect of radiation at the cell level.

For radioresistant patients (those patients who experience reduced or no adverse effects to radiation treatment), a protein named ATM is responsible for the successful recognition and repair of these breaks.

But, for radiosensitive patients, the ATM protein does not do its job completely: some breaks are not repaired. These unrepaired breaks are identified through an immunofluorescence analysis and represent a reliable indicator of the individual patient’s radiosensitivity.

By comparing the number of unrepaired radiation-induced DNA breaks with those that are repaired, our researchers can precisely estimate the radiation therapy dose that the patient will be able to tolerate and still avoid adverse side effects.

Bodgi et al. The enigma of the biological interpretation of the linear-quadratic model finally resolved? A summary for non-mathematicians. Cancer Radiother. 2016 Jun;20(4):314-21

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Our technology is the result of over ten years of research by the Radiobiology Group. Their work on individual sensitivity have allowed to set up predictive tests. This technology offers a promissing solution, optimizing the efficiency of radiotherapy treatments and preventing toxicity at the same time.

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