The COPERNIC project investigators Adeline Granzotto, Mohamed Amine Benadjaoud, Guillaume Vogin, Clément Devic, Mélanie Ferlazzo, Larry Bodgi, Sandrine Pereira, Laurène Sonzogni, Fabien Forcheron, Muriel Viau, Aurélie Etaix, Karim Malek, Laurence Mengue-Bindjeme, Clémence Escoffier, Isabelle Rouvet, Marie-Thérèse Zabot,..Nicolas Foray. “Influence of the nucleo-shuttling of the ATM protein in the healthy tissues response to radiotherapy: towards a molecular classification of human radiosensitivity “ INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2016

Bodgi L, Granzotto A, Devic C, Vogin G, Lesne A, Bottollier-Depois JF, Victor JM, Maalouf M, Fares G, Foray N. A single formula to describe radiation-induced protein relocalization: Towards a mathematical definition of individual radiosensitivity. Journal of theoretical biology 2013;333:135-145.

Rothkamm K, Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proceedings of the National Academy of Sciences of the United States of America 2003;100:5057-5062.

Joubert, A. and N. Foray, [Intrinsic radiosensitivity and DNA double-strand breaks in human cells]. Cancer Radiother, 2007. 11(3): p. 129-42.

Chavaudra, N., J. Bourhis, and N. Foray, Quantified relationship between cellular radiosensitivity, DNA repair defects and chromatin relaxation: a study of 19 human tumour cell lines from different origin. Radiother Oncol, 2004. 73(3): p. 373-82.

 Devic C, Bodgi L, Granzotto A, Ferlazzo ML, Sonzogni L, Bourguignon M, Foray N. Le phénomène d’hypersensibilité aux faibles doses : Une énigme de la radiobiologie enfin résolue ? Revue de médecine nucléaire 2016; in press.

Colin C, Devic, C, Noël, A., Rabilloud, M., Zabot, MT, Pinet-Isaac, S, Giraud, S, Riche B, Valette PJ, Rodriguez-Lafrasse, C, and Foray N. (2011) DNA double-strand breaks induced by mammography screening procedures in human mammary epithelial cells. International Journal of radiation Biology, 87, 1103-1112.

Ferlazzo, M.L., L. Sonzogni, A. Granzotto, L. Bodgi, O. Lartin, C. Devic, G. Vogin, S. Pereira, and N. Foray, Mutations of the Huntington's Disease Protein Impact on the ATM-Dependent Signaling and Repair Pathways of the Radiation-Induced DNA Double-Strand Breaks: Corrective Effect of Statins and Bisphosphonates. Mol Neurobiol, 2014. 49: p. 1200-1211.

Ignacio Varela, Sandrine Pereira, Alejandro P. Ugalde, Claire L. Navarro, María F. Suárez, Pierre Cau, Juan Cadiñanos, Fernando G. Osorio, Nicolas Foray, Juan Cobo, Félix de Carlos, Nicolas Lévy, José M. P. Freije1 & Carlos López-Otín.. 

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nature Medecine. 2008 Jul;14(7):767-7

Gastaldo, J., Viau, M., Bencokova, Z., Joubert, A., Charvet, A.-M., Balosso, J., and Foray, N., 2007. Lead contamination results in late and slowly repairable DNA double-strand breaks and impacts upon the ATM-dependent signaling pathways. Toxicology Letter, 173, 201-214.

Bencokova, Z., Pauron, L., Devic, C., Joubert, A., Gastaldo, J., Massart, C., Balosso, J. , and Foray, N. 2008.  Molecular and cellular response of the most extensively used rodent glioma models to radiation and/or cisplatin. Journal of Neurooncology, 86, 13-21

Gastaldo, J., Viau, M., Bouchot, M., Joubert, A. Charvet, A.M., and Foray, N., 2008, Induction and repair rate of DNA damage: a unified model for describing effects of external and internal irradiation and contamination with heavy metals. Journal of Theoretical Biology. 251, 68-81. 

Viau, M., Gastaldo, J., Bencokova Z., Joubert, A., Foray, N. 2008, Cadmium inhibits non-homologous end-joining and over-activates the MRE11-dependent repair pathway. Mutation Research, 654, 13-21.Mutat Res. 2008


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Our technology is the result of over ten years of research by the Radiobiology Group. Their work on individual sensitivity have allowed to set up predictive tests. This technology offers a promissing solution, optimizing the efficiency of radiotherapy treatments and preventing toxicity at the same time.

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